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COPD exacerbations may continue to occur in patients even if treatment is optimized with triple inhaled therapy.1

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  • Severe exacerbations were defined as those which resulted in hospitalization with a primary discharge diagnosis of COPD2

Despite triple inhaled therapy,c the current standard of care, many patients remain symptomatic as defined by exacerbations​

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In a retrospective study of
patients with COPD,


of patients died 3.6 years (median; range 1 day to 17 years) after their first hospitalization for a severe COPD exacerbation2,a

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After 1 moderate/severe exacerbation

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Mean annual
decline in
postbronchodilator FEV1 (P=0.003)

  • Loss of lung function nearly doubled3
  • Irreversible lung function decline may occur after only one COPD exacerbation3
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Chronic inflammation has an important
role in driving the downward spiral
of COPD progression.4-12

aBased on data from a large population-based cohort of 73,106 Canadian patients (mean age 75 years) who were hospitalized for the first time because of a severe exacerbation of COPD (1990-2005, followed until death or March 31, 2007).2
bAdjusted for age, sex, calendar time, and the modified Chronic Disease Score.2
cOr double inhaled therapy if ICS is contraindicated.13
d52-week, randomized, double-blind, phase 3 trial that assessed the efficacy and safety of fluticasone furoate/umeclidinium/
vilanterol triple therapy versus fluticasone furoate/vilanterol or umeclidinium/vilanterol in patients aged ≥40 years with symptomatic COPD and a history of exacerbations within the year prior to enrollment.1
eFEV1 decline after a single moderate-to-severe exacerbation. Based on a retrospective analysis of data from 586 patients with moderate-to-severe COPD.3
aHR, adjusted hazard ratio; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; QoL, quality of life.
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